Disclosed is a high oxygen permeability material based on marine biological substances, which is formed by compositing a silicon-containing substance and a bioactive substance in the presence of a crosslinking agent； the silicon-containing substance has a siloxy group, and the bioactive substance is at least one selected from alginic acid, collagen, hyaluronic acid and salts thereof. Also disclosed is a method for preparing the high oxygen permeability material, comprising: in acidic conditions, mixing the silicon-containing substance and the bioactive substance, and then crosslinking the resultant mixture in the presence of a crosslinking agent. Also disclosed is the use of the high oxygen permeability material or the method in the preparation of corneal contact lenses, corneal scaffold materials or corneal substitutes. The high oxygen permeability material obtained in the present invention can satisfy the requirement for high oxygen permeability during prolonged wear and has a good wearing comfort. In addition, since the marine biological substances having a good biocompatibility are used, the high oxygen permeability material of the present invention has a good biocompatibility and high safety performance.L'invention concerne un matériau à haute perméabilité à l'oxygène à base de substances biologiques marines, qui est formé par composition d'une substance contenant du silicium et d'une substance bioactive en présence d'un agent de réticulation ； la substance contenant du silicium présentant un groupe siloxy et la substance bioactive étant au moins l'une choisie parmi un acide alginique, le collagène, l'acide hyaluronique et des sels correspondants. L'invention concerne également un procédé de préparation du matériau à haute perméabilité à l'oxygène, consistant à : mélanger, dans des conditions acides, la substance contenant du silicium et la substance bioactive puis à réticuler le mélange résultant en présence d'un agent de réticulation. L'invention concerne éga
