Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
- 专利权人:
- DUKE UNIVERSITY
- 发明人:
- 申请号：
- IL25767718
- 公开号：
- IL257677D0
- 申请日:
- 2018.02.22
- 申请国别(地区):
- IL
- 年份:
- 2018
- 代理人:
- 摘要：
- Disclosed herein are optimized guide RNAs (gRNAs) and methods of designing and using said optimized gRNAs that have increased target binding specificity and reduced off-target binding.
- 来源网站：
- 中国工程科技知识中心
