Described is a medical article comprising a PSA layer comprising acid-functional groups or basic-functional groups, wherein the PSA includes at least 0.42 mmoles acidic- or basic-functional groups per gram PSA; and an MVTR-modifying material that is basic when the PSA comprises acidic-functional groups or is acidic when the PSA comprises basic-functional groups; wherein the MVTR-modifying material is immiscible with the PSA, and reacts with the functional groups of the PSA upon contact to form a poly-salt in the presence of fluid, and wherein the PSA includes an additional hydrophilic polymer component.감압성 접착제층을 포함하는 의료 용품(예컨대, 상처 드레싱) 및 수증기 투과율을 증가시키는 비혼화성 물질을 사용하는 의료 용품의 제조 방법이 제공된다.