Thomas Joseph Sayers,Nancy Lynn Booth,Curtis J. Henrich,Alan David Brooks,Kirk R. Gustafson,Karen L. Erickson
申请号：
US13516514
公开号：
US09238069B2
申请日:
2010.12.16
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with a death receptor ligand, which method comprises contacting the cancer cells with a death receptor ligand in conjunction with an effective amount of a compound described herein, for example, a cucurbitacin (I) or a withanolide (II). Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with a compound described herein, for example, a cucurbitacin (I) or a withanolide (II) and also contacting the cancer cells with a death receptor ligand, whereby apoptosis is induced in the cancer cells.
