The United States of America; Dept. of Health & Human Services Office of Technology Transfer; As Represented by the Secretary
发明人:
申请号：
EP20150087.3
公开号：
EP3659620A1
申请日:
2014.12.16
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Described herein is a method of preventing or treating a disease in a mammalian subject, comprising administering to the subject who is in need thereof an effective dosage of a pharmaceutical composition comprising a virus like particle (VLP) comprising: an alphavirus replicon comprising a recombinant polynucleotide, wherein the polynucleotide comprises a sequence encoding both subunits of a human class II major histocompatibility antigen, a retroviral gag protein, and a fusogenic envelope protein, wherein the VLP does not contain an alphavirus structural protein gene.
