EVALUATION DE TISSUS A L'AIDE DE CARACTERISTIQUES TISSULAIRES DE L'IMAGERIE NON INVASIVE ET SYSTEMES DE DETERMINATION DES CARACTERISTIQUES TISSULAIRES GLOBALES DES IMAGES
HUNDLEY, WILLIAM GREGORY,HAMILTON, CRAIG A.,LANE, KIMBERLY,MORGAN, TIM,TORTI, FRANK
申请号：
CA2555373
公开号：
CA2555373C
申请日:
2005.02.04
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Evaluating tissue characteristics including identification of injured tissueor alteration of the ratios of native tissue components such as shifting theamounts of normal myocytes and fibrotic tissue in the heart, identifyingincreases in the amount of extracellular components or fluid (like edema orextracellular matrix proteins), or detecting infiltration of tumor cells ormediators of inflammation into the tissue of interest in a patient, such as ahuman being, is provided by obtaining a first image of tissue including aregion of interest from a first acquisition, for example, after administrationof a contrast agent to the patient, and obtaining a second image of the tissueincluding the region of interest during a second, subsequent acquisition, forexample, after administration of a contrast agent to the patient. Thesubsequent acquisition may be obtained after a period of time to determine ifinjury has occurred during that period of time. The region of interest mayinclude heart, blood, muscle, brain, nerve, skeletal, skeletal muscle, liver,kidney, lung, pancreas, endocrine, gastrointestinal and/or genitourinarytissue. A global characteristic of the region of interest of the first imageand of the second image is determined to allow a comparison of the globalcharacteristic of the first image and the second image to determine apotential for a change in global tissue characteristics. Such a comparison mayinclude comparison of mean, average characteristics, histogram shape, such asskew and kurtosis, or distribution of intensities within the histogram.
