The invention provides a method for producing mixtures of a drug and polymer that provide improved dissolution (faster or more complete dissolution) compared to pure drug or drug and polymer physical mixtures. The method uses annealing of a mixture of drug and polymer in contact with an adjuvant, which allows improved dissolution to be achieved with shorter annealing times and/or reduced annealing temperatures compared to annealing without an adjuvant, without dissolving the drug and polymer in a solvent and without melting the polymer.
