The disclosure provides anti-DENV antibodies and methods of making and using the same. Nucleic acids encoding the anti-DENV antibodies and host cells comprising the nucleic acids are also provided. The anti-DENV antibodies have uses that include treating DENV infection. The disclosure also provides polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided. The polypeptides have uses that include treating a viral infection.本發明提供一種抗登革熱病毒抗體及其製備和使用方法。亦提供編碼抗登革熱病毒抗體的核酸以及包含該核酸之宿主細胞。抗登革熱病毒抗體具有包含治療登革熱病毒感染的用途。本發明亦提供含有變異Fc區之多肽及其製備與使用方法。亦提供編碼多肽的核酸以及包含該核酸之宿主細胞。多肽具有包含治療病毒感染的用途。
