University of Cape Town;The South African Nuclear Energy Corporation Limited
发明人:
Driver, Cathryn Helena Stanford,Zeevaart, Jan Rijn,Parker, Mohamed Iqbal,Hunter, Roger
申请号：
AU2015323328
公开号：
AU2015323328A1
申请日:
2015.09.25
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
This invention relates new radiopharmaceutical conjugates for use in improved methods of diagnosis and treatment of cancer. The radiopharmaceutical conjugate comprises, in sequence: a metabolite that targets tumour cells, bound to a chelating agent capable of containing a radionuclide, bound to a linker capable of binding with an EPR agent in vitro or in vivo； or a chelating agent capable of containing a radionuclide, bound to a metabolite that targets tumour cells, bound to a linker capable of binding with an EPR agent in vitro or in vivo. The radiopharmaceutical conjugates of the present invention provide active and passive targeted radionuclide delivery systems that can help to improve the biodistribution and pharmacological toxicity of the radiopharmaceuticals used for the diagnosis and therapy of cancer.
