The present invention relates to the use of lipids bearing fatty acids with an odd number of carbon atoms as pharmaceuticals or nutritional supplement. In particular, such lipids are used in the treatment and/or prevention of neurodegenerative diseases, optic and retinal degenerative diseases, demyelinating diseases, neuromuscular disorders and muscular dystrophy, stroke, brain or spinal cord nerve injury, amyloid related diseases, but also a functional food or food supplement for anti-aging or life-span prolongation and brain function improvement for human and/or animals.