Devalaraja-Narashimha, Kishor,Morton, Lori,Luo, Yifan,Huang, Cong,Meagher, Karolina,Casanova, Sarah
申请号：
AU2018225745
公开号：
AU2018225745A1
申请日:
2018.02.26
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
Provided herein, inter alia, are non-human animals comprising nucleic acid sequences encoding a C3 protein that comprises a human sequence as well as transgenic non-human animals comprising a C3 gene that is human in whole or in part as well as methods for using the same to screen for candidate therapeutic molecules to treat complement-related nephropathies. Also provided herein are methods for improving kidney function in an individual diagnosed with or thought to have a complement-related nephropathy.
