Christian FIEDLER,Eva FRITSCHER,Meinhard HASSLACHER,Dominik MITTERGRADNEGGER,Tanvir TABISH
申请号：
US16347107
公开号：
US20190255126A1
申请日:
2017.11.03
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Adeno-associated liquid and lyophilized pharmaceutical compositions are provided herein. In exemplary aspects, the pharmaceutical compositions comprise about 5 mM to about 25 mM L-histidine, about 0 mM to about 150 mM sodium chloride, about 0.001% (w/v) to about 0.01% (w/v) polysorbate 80 (PS80), and about 1% to about 10% (w/v) sucrose, trehalose, or combination thereof to AAV. In exemplary aspects, the pharmaceutical compositions further comprise glycine or mannitol. Methods of preparing a pharmaceutical composition comprising AAV, methods of treating a bleeding disorder in a subject, and methods of storing AAV compositions are also provided.
