Mario Masellis,Joanne Knight,Maureen Shannon Collinson,Anthony Edward Lang,James Lowery Kennedy,Joseph Levy,Amir Tchelet,Iris Grossman,Eli Eyal,Ofra Barnett
申请号：
US14674606
公开号：
US20150275302A1
申请日:
2015.03.31
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This application provides a method for treating a human subject afflicted with Parkinsons disease (PD) with a pharmaceutical composition comprising rasagiline or a pharmaceutically acceptable salt of rasagiline, and a pharmaceutically acceptable carrier, comprising the steps of:(i) obtaining a biological sample comprising a genome from the human subject afflicted with Parkinsons disease(ii) assaying the DNA or RNA of the biological sample from the human subject using a probe or a primer, to determine the diploid genotype of the human subject at single nucleotide polymorphism (SNP) rs1076560 or rs2283265(iii) identifying the human subject as a predicted responder to rasagiline if the diploid genotype is CC at rs1076560, CC at rs2283265, or CC at both rs1076560 and rs2283265 and(iv) administering the pharmaceutical composition comprising rasagiline and a pharmaceutically acceptable carrier to the human subject if the human subject is identified as a predicted responder to rasagiline.
