An injection device (100), provided for injection with an injection syringe (50) into an organism (1), comprises a guide device (10) designed to receive the injection syringe (50), wherein an injection needle (51) and a syringe body (52) of the injection syringe (50) can be moved relative to the guide device (10), in an advance movement towards or in a withdrawal movement away from the organism (1), and an actuating device (20) to which the injection syringe (50) can be coupled and which is used to actuate the injection syringe (50) for injection of an injectable substance into the organism (1), wherein the actuating device (20) has an actuating element (21) which forms an abutment for a piston device (53) of the injection syringe (50) on the guide device (10), in such a way that, during the withdrawal movement, the piston device (53) executes a relative movement counter to the injection needle (51) and the syringe body (52).
