An injection device (100), provided for injection with an injection syringe(50) into an organism (1), comprises a guide device (10) designed to receive theinjection syringe (50), wherein an injection needle (51) and a syringe body (52)of the injection syringe (50) can be moved relative to the guide device (10), inan advance movement towards or in a withdrawal movement away from the organism(1), and an actuating device (20) to which the injection syringe (50) can be coupledand which is used to actuate the injection syringe (50) for injection of an injectablesubstance into the organism (1), wherein the actuating device (20) has an actuatingelement (21) which forms an abutment for a piston device (53) of the injectionsyringe (50) on the guide device (10), in such a way that, during the withdrawalmovement, the piston device (53) executes a relative movement counter to theinjection needle (51) and the syringe body (52).
