An injection device (100), provided for injection with an injection syringe(50) into an organism (1), comprises aguide device (10) designed to receive the injection syringe (50), wherein aninjection needle (51) and a syringe body (52) of theinjection syringe (50) can be moved relative to the guide device (10), in anadvance movement towards or in a withdrawal movementaway from the organism (1), and an actuating device (20) to which theinjection syringe (50) can be coupled and which is used toactuate the injection syringe (50) for injection of an injectable substanceinto the organism (1), wherein the actuating device (20) hasan actuating element (21) which forms an abutment for a piston device (53) ofthe injection syringe (50) on the guide device (10),in such a way that, during the withdrawal movement, the piston device (53)executes a relative movement counter to the injectionneedle (51) and the syringe body (52).
