AMELIORATION DE L'ACTIVITE ET DE LA DUREE D'ACTION DE STEROIDES ANTI-INFLAMMATOIRES SELECTIONNES

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专利权人:

BODOR; NICHOLAS S.

发明人:

BODOR, NICHOLAS S.

申请号：

CA2558941

公开号：

CA2558941C

申请日:

2004.06.17

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

Methods and compositions for enhancing the activity and/or duration of actionof soft anti-inflammatory steroids of the haloalkyl 17a-alkoxy-11.szlig.-hydroxyandrost-4-en-3-one-17.szlig.-carboxylate type and the corresponding 1,4compounds and of anti-inflammatory steroids of the hydrocortisone andprednisolone type are described. The enhancing agents have the formula:wherein R is H or C1-C4 alkyl； Z1 is carbonyl or .szlig.-hydroxymethylene； X1is -O- or -S-； R5 is -OH, -OR6, -OCOOR6 or -OCOR7 wherein R6 is C1-C4 alkyland R7 is C1-C4 alkyl, fluoromethyl or chloromethyl； and the dotted line inring A indicates that the 1,2-linkage is saturated or unsaturated； with theproviso that when R is C1-C4 alkyl, then R5 is -OH.

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