President and Fellows of Harvard College;Children's Medical Center Corporation
发明人:
Ingber Donald E.,Torisawa Yusuke,Hamilton Geraldine,Mammoto Akiko,Mammoto Tadanori,Spina Catherine
申请号：
US201214122273
公开号：
US9951313(B2)
申请日:
2012.05.31
申请国别(地区):
美国
年份:
2018
代理人:
Nixon Peabody LLP `Resnick David S.`Kling Nicole D.
摘要：
The technology described herein is directed to methods and devices that can be used to induce functional organ structures to form within an implantation device by implanting it in vivo within the body of a living animal, and allowing cells and tissues to impregnate the implantation device and establish normal microenvironmental architecture and tissue-tissue interfaces. Then the contained cells and tissues can be surgically removed intact and either transplanted into another animal or maintained ex vivo by perfusing it through one or more of the fluid channels with medium and/or gases necessary for cell survival.
