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DISINTEGRATING PARTICLE COMPOSITION PRODUCED BY TWO-STAGE WET GRANULATION PROCESS, AND INTRAORALLY DISINTEGRATING TABLET CONTAINING SAME COMPOSITION
专利权人:
Daicel Corporation
发明人:
HIRAMURA, Takahiro,IKURA, Kiyoshi,ITAYA, Sae,OKABAYASHI, Tomohito,HASHIKAWA, Naohiro,SAKAGUCHI, Anan
申请号:
EP14848578
公开号:
EP3050575A4
申请日:
2014.09.24
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
An object of the present invention is to provide a disintegrative particulate composition that can be used for an orally disintegrating tablet having both excellent tablet hardness and disintegrability. This invention relates to a method for the production of a disintegrative particulate composition including three components consisting of a first disintegrator component having sedimentation volume in water of 4.0 cm3/g or more, a second disintegrator component other than the first disintegrator component and an excipient, which comprises a first wet granulation step using any two of the three components and a second wet granulation step using the granules obtained in the first wet granulation step and at least the remaining one component not used in the first wet granulation step the disintegrative particulate composition thus produced and an orally disintegrating tablet comprising a medicinal ingredient and the disintegrative particulate composition.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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