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DISINTEGRATING PARTICLE COMPOSITION PRODUCED BY TWO-STAGE WET GRANULATION PROCESS, AND INTRAORALLY DISINTEGRATING TABLET CONTAINING SAME COMPOSITION
专利权人:
DAICEL CORPORATION
发明人:
Takahiro HIRAMURA,Kiyoshi IKURA,Sae ITAYA,Tomohito OKABAYASHI,Nohiro HASHIKAWA,Anan SAKAGUCHI
申请号:
US15021647
公开号:
US20160250144A1
申请日:
2014.09.24
申请国别(地区):
US
年份:
2016
代理人:
摘要:
An object of the present invention is to provide a disintegrative particulate composition that can be used for an orally disintegrating tablet having both excellent tablet hardness and disintegrability.This invention relates to a method for the production of a disintegrative particulate composition including three components consisting of a first disintegrator component having sedimentation volume in water of 4.0 cm3/g or more, a second disintegrator component other than the first disintegrator component and an excipient, which comprises a first wet granulation step using any two of the three components and a second wet granulation step using the granules obtained in the first wet granulation step and at least the remaining one component not used in the first wet granulation step; the disintegrative particulate composition thus produced; and an orally disintegrating tablet comprising a medicinal ingredient and the disintegrative particulate composition.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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