DIXIT, SURJIT BHIMARAO,SPRETER VON KREUDENSTEIN, THOMAS,NG, GORDON, YIU KON,WEISSER, NINA E.
申请号：
EP13816697
公开号：
EP2872170A4
申请日:
2013.07.13
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
Disclosed herein are isolated multi-specific heteromultimer constructs that bind to CD3 expressed on T-cells and to an antigen expressed on B-cells. The multi-specific heteromultimer constructs are capable of bridging T- and B-cells and mediating killing of B-cells. The multi-specific heteromultimer constructs are based on a heterodimeric Fc scaffold or on a segmented albumin scaffold. Also disclosed herein are multi-specific heteromultimer constructs that bind to HER2 and HER3.
