The present invention discloses a compression device for artificial valve replacing device that comprises at least two clamp unit blocks connecting with each other in sequence and enclosing a compressing channel. The compression device further comprises a guide structure for leading all clamp unit blocks to retract towards the center of the compressing channel. In this invention, when the artificial valve replacing device is placed in the compressing channel, the inner wall of the compressing channel props against the peripheral wall of the artificial valve replacing device. When the clamp unit blocks are retracting towards the center of the compressing channel under the action of outside force, the inner wall of the compressing channel applies the force directing to the center of the compressing channel. The device has the low manufacturing cost and is convenient to clean due to the simple structure, fully satisfying the requirements for operation sanitation in use. Therefore, the production and maintenance costs are reduced and the expense shifted to consumers is lowered.