Disclosed herein are [1,2,4]thiadiazine 1,1-dioxide compounds for example N-{ 3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-azatricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1-benzo[1,2,4]thiadiazin-7-ylmethyl} -methane sulfonamide and pharmaceutically acceptable salts thereof and their use in the manufacture of medicaments for treatment of hyperuricemia and gout.