ROBINSON, Simon P.,CASEBIER, David S.,YU, Ming,KAGAN, Mikhail,LAZEWATSKY, Joel
申请号：
ES09716528
公开号：
ES2767973T3
申请日:
2009.02.27
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A method of imaging at least a part of the brain or at least a part of the central nervous system in a human subject, comprising: administering to the subject a contrast agent having the structure ** Formula ** wherein J is selected of N (R27), S, O, C (= O), C (= O) O, NHCH2CH2O, a bond, or C (= O) N (R27)； K and L, when present, are independently selected from hydrogen, alkoxyalkyl, alkyloxy, aryl, alkyl, heteroaryl, and an imaging moiety, each of which is optionally substituted； M is selected from alkoxyalkyl and alkyloxy, each of which is optionally substituted, or L and M, together with the atom to which they are attached, form a ring, optionally substituted； Q is halo or haloalkyl； n is 0, 1, 2 or 3； R21, R22, R23, R24, R25, R26, and R27 are independently selected from hydrogen, alkyl, optionally substituted, and an imaging moiety； R29 is alkyl, optionally substituted； and Y is selected from carbon and oxygen, provided that when Y is oxygen, K and L are absent and M is optionally substituted alkoxyalkyl, wherein at least one imaging moiety is present in Formula (II)； and wherein said optional substituent is selected from one or more of the following: alkyl, alkenyl, cycloalkyl, alkylaryl, alkylcarbonyl, aryl, arylalkyl, alkylarylalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, heteroalkyl, heterocyclyl, heterocyclylalkyl, amino, thio, - OH, phosphate, -CO2H, = O, halo, trifluoromethyl, nitro, cyano, ester, aldehyde, amide, keto, azide, sulfhydryl, imino, phosphonate, phosphinate, carbonyl, carboxyl, silyl, ether, alkylthio, sulfonyl, sulfonamide or an image rest； optionally, wherein K and L, when present, are independently selected from hydrogen, alkoxyalkyl, alkyloxy, aryl, heteroaryl, and an imaging moiety, each of which is optionally substituted； or, optionally, where J is O and R29 is C1-C6 alkyl； or, optionally, where R29 is tert-butyl； or, optionally, where K, L or M is alkoxyalkyl, optionally substituted with an imaging moiety； or, optionally, where M is alk
