In an embodiment, an X-ray diagnostic apparatus includes an X-ray irradiator which irradiates a subject with X-rays, an X-ray detector which detects the X-rays emitted from the X-ray irradiator and passing through the subject, a movement mechanism which changes a position of the X-ray detector relative to the subject, a display unit which displays an X-ray image based on the X-rays detected by the X-ray detector, a region setting unit which sets a region of interest in the X-ray image displayed in a display screen of the display unit, and a movement control unit which controls the movement mechanism in such a way that the region of interest set by the region setting unit is kept in the display screen.