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COMPOSITIONS AND METHODS FOR PRESERVING PLATELET FUNCTION
专利权人:
发明人:
Lakshman R. SEHGAL
申请号:
US14510915
公开号:
US20150056604A1
申请日:
2014.10.09
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Compositions and methods for maintaining platelet functionality and extending the shelf-life of platelets are described. Platelet preservation compositions include a photosensitizer and a plurality of platelet preservation agents. A method for preserving platelets and extending their shelf-life includes irradiating a platelet mixture containing a photosensitizer under conditions sufficient to activate the photosensitizer and inactivate microbes in the platelet mixture to form a microbe-depleted platelet preparation. A plurality of platelet preservation agents are added to the microbe-depleted platelet preparation for extending the platelet shelf-life. Prior to transfusion, the photosensitizer and platelet preservation agents can be removed by diafiltration and/or the use of compound adsorption devices.
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