The Board of Trustees of The University of Arkansas;The Texas A&M University System
发明人:
BERGHMAN, Luc,BOTTJE, Walter,LAYTON, Sherryll,HARGIS, Billy
申请号:
DK11735230
公开号:
DK2525817T3
申请日:
2011.01.21
申请国别(地区):
DK
年份:
2017
代理人:
摘要:
Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.