PROBLEM TO BE SOLVED: To provide S100A8 expression inhibitors useful for the prevention or treatment of different symptoms and diseases caused by the excessive expression of S100A8.SOLUTION: S100A8 expression inhibitors comprise a plant or its extract selected from Scopolia japonica and California poppy as an active ingredient.COPYRIGHT: (C)2016,JPO&INPIT【課題】S100A8の過剰発現に関連して生じる各種症状や疾患の予防又は治療に有用な、S100A8発現抑制剤の提供。【解決手段】ハシリドコロ及びハナビシソウから選ばれる植物又はその抽出物を有効成分とするS100A8発現抑制剤。【選択図】なし