PROBLEM TO BE SOLVED: To provide effective cancer therapeutic means through PSF1 gene expression inhibitory activity.SOLUTION: There is provided a PSF1 gene expression inhibitor having PSF1 gene expression inhibitory activity and comprising hydrous lower alcohol extract of Cardiocrinum plants. The PSF1 gene expression inhibitor is a cancer preventive or therapeutic agent. Preferably, hydrous lower alcohol extract from leaves of Cardiocrinum plants is used.COPYRIGHT: (C)2015,JPO&INPIT【課題】PSF1遺伝子の発現抑制活性を通じた、より効果的ながんの治療手段の提供。【解決手段】PSF1遺伝子発現抑制活性を有する、ウバユリの含水低級アルコール抽出物を含む、PSF1遺伝子発現抑制剤。がんの予防又は治療剤である、該PSF1遺伝子発現抑制剤。ウバユリの葉からの含水低級アルコール抽出物が好ましい。【選択図】図2