Eduardo A. Padlan;Masanori Numazaki;Sadakazu Usuda;Tetsuo Nakamura
发明人:
Masanori Numazaki,Tetsuo Nakamura,Sadakazu Usuda,Eduardo A. Padlan
申请号：
US11910429
公开号：
US08101179B2
申请日:
2006.03.31
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A murine anti-CD20 monoclonal antibody having cell growth inhibitory activities is disclosed. Cell growth inhibitory activities include apoptosis against human CD20 antigen expressing cells in culture of the CD20 antigen expressing cells without effector cells. The anti-CD20 monoclonal antibody is incorporated into chimeric anti-CD20 monoclonal antibodies in which the amino acid sequences of the variable regions of the anti-CD20 monoclonal antibody and the amino acid sequences of the constant regions of human immunoglobulin are fused. Also a humanized anti-CD20 monoclonal antibody is described which includes all of the variable region CDRs of the H chain of the anti-CD20 monoclonal antibody and all of the variable region CDRs of the L chain of the anti-CD20 monoclonal antibody and an amino acid sequence of human immunoglobulin. A nucleotide sequence encoding the amino acid sequence of the chimeric or humanized anti-CD20 monoclonal antibody can be expressed in mammalian cells.
