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T-CELL-SPECIFIC HUMANIZED SINGLE FRAGMENT ANTIBODY DELIVERY VEHICLE
专利权人:
发明人:
Sang Kyung LEE,Hyo Jeong HONG,Priti KUMAR
申请号:
US14654273
公开号:
US20160060341A1
申请日:
2013.03.05
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention relates to a humanized scFv delivery vehicle targeted to be human T-cell specific, and provides: a humanized scFv which comprises a heavy-chain variable region (VH) consisting of a polypeptide comprising an amino acid sequence given by sequence number 32 and comprises a light-chain variable region (VL) consisting of a polypeptide comprising an amino acid sequence given by sequence number 34 and a T-cell-specific drug or marker delivery vehicle comprising the humanized scFv. The humanized scFv of the present invention has minimalised antigenicity and has an effect which does not give rise to an immune reaction even when used in the human body, and thus can advantageously be used as a delivery vehicle for specifically delivering a target substance such as a siRNA gene or an immune reaction regulating protein to T-cells.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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