A pharmaceutical composition includes an effective amount of a peptide or an analog thereof, and a pharmaceutically tolerable excipient, wherein the peptide includes the amino acid sequence of SEQ ID NO. 17. An analog of a peptide including the amino acid sequence of SEQ ID NO. 17, wherein one or more amino acids residues are modified by a) C-terminal modification； b) D-amino acid substitution； and/or c) deletion of one or more amino acid residues. A method of inhibiting the growth of a microorganism includes contacting the microorganism in a medium with an effective amount of a peptide or an analog thereof, wherein the peptide includes the amino acid sequence of SEQ ID NO. 17. A method of treating a disease or disorder associated with microbial activity in a subject includes administering an effective amount of a peptide or an analog thereof to the subject, the peptide including the amino acid sequence of SEQ ID NO. 17.
