Dominik Haudenschild,Paul Di Cesare,Jasper Yik,Blaine Christiansen
申请号：
US14351878
公开号：
US09498471B2
申请日:
2012.10.19
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to the use of cyclin-dependent kinase 9 (CDK9) inhibitors to reduce, inhibit and/or prevent cartilage degradation. CDK9 inhibitors can be used to reduce, inhibit and/or prevent cartilage degradation and loss of cartilage viability during allograft storage. CDK9 inhibitors can be used as a post-injury intervention treatment to reduce, inhibit and/or prevent the acute cellular responses that lead to future cartilage degradation and osteoarthritis.
