Samsung Life Public Welfare Foundation;Korea Institute of Science and Technology
发明人:
Sang Jun Kim,Young Mee Jung,Soo Hyun Kim
申请号：
US15556963
公开号：
US10434135B2
申请日:
2016.03.14
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A pharmaceutical composition for preventing or treating arthritis, which comprises synthetic polypeptides； injections for preventing or treating arthritis； and a pharmaceutical composition for inducing differentiation of cartilage cells are described herein. Synthetic polypeptides of the present invention consisting of a polypeptide represented by SEQ ID NO: 1 and a polypeptide represented by SEQ ID NO: 2 have activity for recruiting stem cells to an arthritis region, inhibit apoptosis of cartilage cells, and exhibit anti-inflammatory activity and activity for promoting regeneration of cartilage cells. Thus, unlike a conventional arthritis treatment agent, the synthetic polypeptides can improve cartilage damage, can inhibit degenerative changes per se and can, at the same time, exhibit an effect as a stem cell treatment agent, and thereby can be usefully utilized as an arthritis prevention or treatment agent.
