The use of a seed or extract thereof from the plant of the genus Capsicum for treating or alleviating the symptoms for psoriasis, acne, dandruff, epidermolysis bullosa and dermatitis. The seed or extract is to be substantially free of capsaicin and other capsaicinoids and comprises a saponin and a triterpene or triterpenoid. The plant can be C. annuum or C. frutescens.