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Trk inhibitor compound
专利权人:
Ltd.;ONO Pharmaceutical Co.
发明人:
TAKEUCHI, Jun,IKURA, Masahiro,HIGASHINO, Masato,IWAHASHI, Maki,HASHIMURA, Kazuya
申请号:
ES13782584
公开号:
ES2605388T3
申请日:
2013.04.25
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound represented by the general formula (I): ** Formula ** in which: a Cy1 ring represents a monocyclic carbocycle or C3-10 bicyclic carbocycle or a 4 to 10 membered monocyclic heterocyclic or bicyclic heterocycle; R1 represents: (1) a halogen, (2) a C1-6 alkyl group optionally substituted with a halogen or an oxo group; (3) a C3-6 cycloalkyl group optionally substituted with a halogen or a C1-3 alkyl group, (4) a C1-6 alkyl group having an oxygen atom replacing a carbon atom and optionally substituted with a halogen or an oxo group; or (5) a C3-6 cycloalkyl group having an oxygen atom replacing a carbon atom and optionally substituted with a halogen or a C1-3 alkyl group; R2 represents: (1) a C1-6 alkyl group, a C2-6 alkenyl group or a C2-6 alkynyl group optionally substituted with a substituent selected from the group consisting of: (i) a halogen, (ii) a group hydroxy; (iii) -NH (C1-3 alkyl); (iv) -N (C1-3 alkyl) 2; (v) an amino group; (vi) a cyano group; (vii) a nitro group; (viii) a C1-4 alkylsulfonyl group, (ix) a sulfonamide group, (x) a C1-4 alkylsulfonamide group; (xi) an oxo group; (xii) a carboxyl group; (xiii) -C (O) (O-C1-4 alkyl), (xiv) a phosphonooxy group; (xv) -OP (O) (O-C1-4 alkyl) 2; (xvi) a carbamoyl group, (xvii) a C1-4 alkylamide group; and (xviii) a C1-4 alkylcarbamate group; (2) a hydrogen atom, (3) a hydroxy group, (4) a carboxyl group; (5) -C (O) (O-C 1-4 alkyl), (6) a phosphonooxy group; (7) -OP (O) (O-C1-4 alkyl) 2; (8) an amino group; (9) a cyano group, (10) a nitro group, (11) a C1-4 alkylsulfonyl group, (12) a sulfonamide group, (13) a C1-4 alkylsulfonamide group; (14) an oxo group; (15) a carbamoyl group, (16) a C1-4 alkylamide group,Un compuesto representado por la formula general (I):**Fórmula** en la que: un anillo Cy1 representa un carbociclo monociclico o carbociclo biciclico C3-10 o un heterociclo monociclico o heterociclo biciclico de 4 a 10 miembros; R1 representa: (1) un halogeno, (2) un grupo alquilo C1-6 opcionalmente
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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