INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS

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专利权人:

The Regents of the University of California

发明人:

Alan S. Verkman,Ricardo De La Fuente Gonzalez

申请号：

US14688365

公开号：

US20150290175A1

申请日:

2015.04.16

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Provided herein are methods for identifying compounds that are inhibitors of a calcium-activated chloride channel. Aminothiophene and aminothiazole compounds, and compositions comprising these compounds, described herein that inhibit efflux of chloride through a calcium-activated chloride channel are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased chloride and fluid secretion, for example, secretory diarrhea.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/