The Board of Trustees of the Leland Stanford Junior University
发明人:
Anna K. Koster,Justin Du Bois,Merritt C. Maduke
申请号：
US16449021
公开号：
US20200016103A1
申请日:
2019.06.21
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are small-molecules for use in modulating chloride ion channel (CLC) activity, particularly the activity of CLC-2, to elucidate the role of CLC-2 in disorders associated with CLC-2 malfunction, and to identify therapeutic leads for their treatment. Compositions and methods for modulating CLC activity are also provided. In certain aspects, the subject compounds and compositions are useful for imaging or channel pull-down studies.
