David Bar-Or,C. Gerald Curtis,Nagaraja K.R. Rao,Greg Thomas
申请号：
US14454917
公开号：
US20150051223A1
申请日:
2014.08.08
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of the formula:wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.
