C. Gerald Curtis;Nagaraja K. R. Rao;David Bar-Or;Greg Thomas
发明人:
David Bar-Or,C. Gerald Curtis,Nagaraja K. R. Rao,Greg Thomas
申请号：
US10397964
公开号：
US08455517B2
申请日:
2003.03.25
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of the formula:wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.
