MODULATEURS D'ARN DE VOÛTE DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE MALADIES

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专利权人:

European Molecular Biology Laboratory

发明人:

申请号：

EP16176740.5

公开号：

EP3263704A1

申请日:

2016.06.28

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention relates to the finding that vault RNAs (vtRNA) associate with p62, an important factor of cellular autophagy. The invention provides the modulation of the binding of vtRNA to p62 as a novel strategy to influence autophagic flux in cells. Thus, the present invention provides inhibitors of vtRNA for use in the treatment of diseases associated with a pathological reduced or insufficient autophagy in cells, such as cancer and neurodegenerative disorders. Further provided are methods for screening novel therapeutic compounds modulating autophagy via the p62/vtRNA axis.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/