KRIKSUNOV, LEO B.,SOWDEN, HARRY S.,LUBER, JOSEPH R.,BUNICK, FRANK J.
申请号：
CA2775054
公开号：
CA2775054C
申请日:
2010.09.23
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
In one aspect, the present invention features a process for making a tablet including a pharmaceutically active agent wherein the tablet has both an immediate release region and a modified release region. The method includes the steps of: (a) forming a tablet shape including a powder blend containing a pharmaceutically active agent and a thermally-sensitive material； and (b) applying energy in different amounts to different regions of the tablet shape to form the tablet in a manner such that: (i) a first region of the tablet shape is exposed to said energy for a sufficient period of time to melt the thermally-sensitive material within the first region to form said modified release region of said tablet； and (ii) a second region of said tablet shape is not so exposed to the energy such that said second region forms the immediate release region of said tablet.
