Leo B. Kriksunov,Harry S. Sowden,Joseph R. Luber,Frank J. Bunick
申请号：
US12887560
公开号：
US08313768B2
申请日:
2010.09.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
In one aspect, the present invention features a process for making a tablet including a pharmaceutically active agent wherein the tablet has both an immediate release region and a modified release region. The method includes the steps of: (a) forming a tablet shape including a powder blend containing a pharmaceutically active agent and a thermally-sensitive material and (b) applying energy in different amounts to different regions of the tablet shape to form the tablet in a manner such that: (i) a first region of the tablet shape is exposed to said energy for a sufficient period of time to melt the thermally-sensitive material within the first region to form said modified release region of said tablet and (ii) a second region of said tablet shape is not so exposed to the energy such that said second region forms the immediate release region of said tablet.
