您的位置: 首页 > 农业专利 > 详情页

siRNA compositions and methods for potently inhibiting viral infection
专利权人:
Bojian Zheng;Yongping Lin;Hongyan Sui
发明人:
Bojian Zheng,Hongyan Sui,Yongping Lin
申请号:
US12636234
公开号:
US08664188B2
申请日:
2009.12.11
申请国别(地区):
US
年份:
2014
代理人:
摘要:
No antiviral regimen has been consistently successful in treating H5N1 virus infection. We demonstrate that a group of highly effective siRNAs targeting different H5N1 viral genes shares a unique motif, GGAGU/ACUCC. We further demonstrate that the effectiveness of siRNAs containing this motif is not sequence specific. The results suggested that the structure of the unique motif is critical in determining the potency of siRNA-mediated protective effects against viral infection and this potent in vivo protection is associated with early productions of β-defensin and IL-6 induced by the motif. Provided are methods and prophylactic and therapeutic agents useful against other viral infections in addition to the H5N1 influenza virus.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充