HAN, BO RAM,PARK, HAN OH,SHIN, MI SIK,LEE, SAM YOUNG
申请号：
AU2010248239
公开号：
AU2010248239B2
申请日:
2010.05.13
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The present invention relates to an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalentely bonding siRNA and a polymeric compound for improving the biostability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the biostability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relatively low concentration. Therefore, the conjugate can advantageously be used not only as an siRNA treatment tool for cancers and other infectious diseases, but also as a novel type siRNA delivery system.
