David A. Ralph,Michael Rosol,Ahmad Ismail,Allison Kissling,Frederick O. Cope,Bonnie Chandler Abbruzzese
申请号：
US16773512
公开号：
US20200237937A1
申请日:
2020.01.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Compositions and methods are disclosed for assessing macrophage involvement in the inflammation of one or more joints of a subject. In certain aspects, the disclosed method includes the steps of administering to the subject a composition comprising a mannosylated dextran construct with an imaging moiety conjugated thereto； acquiring one or more planar images of a first joint of the subject； defining a region of interest (ROI) comprising the first joint； defining a joint specific reference region (RR)； determining a MARTAD value of the joint by assessing the ratio of average pixel intensity of the ROI to the average pixel intensity of the RR； and comparing the MARTAD of the first joint to a normal MARTAD value for a corresponding joint, and wherein macrophage involvement is indicated by a joint specific MARTAD value that exceeds the normal MARTAD value by a predetermined threshold.
