RAPPLEYE, CHAD,ZUKIWSKI, ALEXANDER,PRONIUK, STEFAN
申请号：
CA2973698
公开号：
CA2973698A1
申请日:
2016.01.07
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Compositions and methods for inhibiting fungal growth by administering AR-12 to a host infected with a fungus such as Histoplasma capsulatum, Aspergillusfumigatus, and Trichophyton rubrum, Paecilomyces, Rhizopus, Fusarium, Scedosporium, Lomentospora, Apophysomyces, Coccidioides, Blastomyces, non-albicans Candida, and Pneumocytis are provided. Aspects described herein provide methods and composition for inhibiting fungal infections in a host. As described herein, AR-12 can be administered to fungus or fungal cells to inhibit or reduce the growth of fungus. In another aspect, AR-12 can be administered to a mammal infected with a fungus to inhibit or reduce the growth of the fungus or to treat a condition caused by the fungus. The route of administration for AR-12 can be any suitable route used for current antifungal treatments (e.g., topical, oral, ophthalmic, intravenous, intranasal, inhalation, transdermal).
