Compositions and methods for inhibiting fungal growth by administering AR 12 to a host infected with a fungus such as Histoplasma capsulatum Aspergillusfumigatus and Trichophyton rubrum Paecilomyces Rhizopus Fusarium Scedosporium Lomentospora Apophysomyces Coccidioides Blastomyces non albicans Candida and Pneumocytis are provided. Aspects described herein provide methods and composition for inhibiting fungal infections in a host. As described herein AR 12 can be administered to fungus or fungal cells to inhibit or reduce the growth of fungus. In another aspect AR 12 can be administered to a mammal infected with a fungus to inhibit or reduce the growth of the fungus or to treat a condition caused by the fungus. The route of administration for AR 12 can be any suitable route used for current antifungal treatments (e.g. topical oral ophthalmic intravenous intranasal inhalation transdermal).
