Novel synthetic routes, which are highly applicable for industrial preparationof therapeutically beneficial oxidized phospholipids are disclosed.Particularly, novel methods for efficiently preparing compounds having aglycerolic backbone and one or more oxidized moieties attached to theglycerolic backbone, which are devoid of column chromatography are disclosed.Further disclosed are novel methods of introducing phosphorous-containingmoieties such as phosphate moieties to compounds having glycerolic backboneand intermediates formed thereby.