AN ADVANCED AND COST-EFFECTIVE PROCESS FOR PREPARING HIGHLY PURE VILDAGLIPTIN

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专利权人:

Harman Finochem Limited

发明人:

KADAM, Vijay Trimbak,BUDDHALA, Rajasekhar Rao,SINGAMPALLLI, Sri Hari,MINHAS, Harpreet Singh,MINHAS, Gurpreet Singh

申请号：

EP14870835

公开号：

EP3082801A4

申请日:

2014.09.01

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The present invention describes an improved process for preparing highly pure (S)-1-[N- (3-hydroxy-l-adamantyl) glycyl] pyrrolidine-2-carbonitrile known as Vildagliptin. Also the present invention discloses a novel insitu process for preparing an intermediate (2S)- l-(chloroacetyl)pyrrolidine-2-carbonitrile. Further, the present invention discloses a method of preparing undesired dimer impurity.

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